The role of low plasma thiamin levels in cognitively impaired elderly patients presenting with acute behavioral disturbances. Clin Res Cardiol. BMC Med. However, the FNB noted that in spite of the lack of reported adverse events, excessive intakes of thiamin could have adverse effects. Vitamin B6, also calledPyridoxine hydrochloride, is one of 8 B vitamins. Theres no upper limit set on thiamine supplements. Institute of Medicine. Estimated Average Requirement (EAR): Average daily level of intake estimated to meet the requirements of 50% of healthy individuals; usually used to assess the nutrient intakes of groups of people and to plan nutritionally adequate diets for them; can also be used to assess the nutrient intakes of individuals. Papila B, Yildiz O, Tural D, Delil S, Hasiloglu ZI, Ayan F, et al. Since most ingredients are listed using their chemical name, it's difficult to figure out if they are halal or not. Thiamine Deficiency and Its Prevention and Control in Major Emergencies, Breakfast cereals, fortified with 100% of the DV for thiamin, 1 serving, English muffin, plain, enriched, 1 muffin, Mussels, blue, cooked, moist heat, 3 ounces, Tuna, Bluefin, cooked, dry heat, 3 ounces, Rice, brown, long grain, not enriched, cooked, cup, Rice, white, long grain, enriched, cooked, cup, Orange juice, prepared from concentrate, 1 cup, Beef steak, bottom round, trimmed of fat, braised, 3 ounces, Oatmeal, regular and quick, unenriched, cooked with water, cup, Chicken, meat and skin, roasted, 3 ounces. Innov Clin Neurosci. Few studies have assessed the prevalence of thiamin deficiency in people with Alzheimers disease. [, Day E, Bentham PW, Callaghan R, Kuruvilla T, George S. Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol. Dairy products and most fruits contain little thiamin [3]. A deficiency of thiamine, or vitamin B1, may go undiagnosed and is associated with poor health outcomes, including death. -Hydroxypropyl starch phosphate For that reason, a deficiency may lead to a lack of certain enzymes. Thiamine plays a role in metabolizing glucose (sugar), which is part of the process used by the body to provide cells with energy. Osiezagha K, Ali S, Freeman C, Barker NC, Jabeen S, Maitra S, Olagbemiro Y, Richie W, Bailey RK. Whether thiamin supplements are effective for preventing thiamin deficiency in patients taking loop diuretics needs to be determined in clinical studies. The discovery of thiamin. Hydrolysed, peptide-based feed (99% peptides and 1% free amino acid) Contains 70% of fat as MCT Lactose and Gluten free Suitable for oral feeding or tube feeding Suitable as sole source of nutrition Halal certified DOSAGE RECOMMENDATIONS: Use as directed by Health Care Professional for oral supplement or enteral tube feed. Cochrane Database Syst Rev 2013;7:CD004033. EFSA J 2008;864:1-31. A focused review. 2020;12:e8027. Rates of deficiency were even higher when the investigators excluded those who used thiamin supplements. Cureus. Hi, i just want to know about niacin and thiamin. The study found that mental decline was less in those who received thiamine. Antioxid Redox Signal 2007;9:1605-19. Should people with diabetes take a thiamine supplement? The authors of one study reported that 33% of 100 patients with chronic heart failure had thiamin deficiency compared to 12% of 50 healthy volunteers [49]. Two randomized double-blind placebo-controlled trials (those in which neither the researchers nor participants know whether they received the active ingredient) compared oral thiamine and injections of thiamine forWernicke-Korsakoff syndrome. The total thiamine pool in the average adult is about 30 mg. An intake of 0.5 mg per 1000 kcal per day . In these trials, thiamin supplements significantly improved net change in left ventricular ejection fraction. The bodys cells need thiamine in order to generate energy, develop, grow, and function. A more common manifestation of thiamin deficiency in the United States is Wernicke-Korsakoff syndrome [2]. Adequate Intake (AI): Intake at this level is assumed to ensure nutritional adequacy; established when evidence is insufficient to develop an RDA. Fluorouracil (also known as 5-fluorouracil; Adrucil) is a chemotherapy drug that is commonly used to treat colorectal and other solid cancers. This syndrome is a late stage of thiamine deficiency. About half of the thiamin in the U.S. diet comes from foods that naturally contain thiamin; the remainder comes from foods to which thiamin has been added [9]. Cochrane Database Syst Rev 2001:CD001498. The body uses thiamine to get the energy to grow cells and support body functions. Other studies have shown a higher risk of thiamin deficiency in people with type 1 and/or type 2 diabetes based on tests of erythrocyte transketolase activity [33,34]. The prevalence of thiamin deficiency in hospitalized patients with congestive heart failure. Any mention in this publication of a specific product or service, or recommendation from an organization or professional society, does not represent an endorsement by ODS of that product, service, or expert advice. Well-designed studies with larger sample sizes and longer durations are required to determine whether thiamin supplements can reduce glucose levels in patients with diabetes or decrease diabetic compications. A trial of thiamine in Alzheimer's disease. However, certain groups of people may have a deficiency, either because they cant get enough thiamine in their diet or their bodies cant absorb it properly. It is essential to read the ingredient list and nutrition facts panel of a supplement carefully to know which ingredients and how much of each ingredient is included. Diabetologia 2007;50:2164-70. Several food sources of thiamin are listed in Table 2. Nutr Clin Pract. The authors used several tools to measure the cognitive (thinking and memory) levels of the people in the trial over time. Therefore, one will have to ask the manufacturer to confirm the source of the doubtful ingredients. It should be discarded after the expiration date on the packaging has passed. Clin Ther. Guidelines from the American Society for Metabolic and Bariatric Surgery also recommend that thiamine levels be tested in people who have gastric surgery and are at risk for a thiamine deficiency. Its not thought that supplementing with thiamine causes any adverse side effects. For healthy adults in the United States, a balanced diet usually provides enough thiamine. Thiamin. For adults, excretion of less than 100 mcg/day thiamin in urine suggests insufficient thiamin intake, and less than 40 mcg/day indicates an extremely low intake [6]. Includes a variety of vegetables; fruits; grains (at least half whole grains); fat-free and low-fat milk, yogurt, and cheese; and oils. Water-soluble vitamins are stored in the body in limited amounts. We can get the recommended amounts of thiamin by eating a variety of foods. Thiamine vitamins are necessary for keeping the. DiNicolantonio JJ, Lavie CJ, Niazi AK, O'Keefe JH, Hu T. Effects of thiamine on cardiac function in patients with systolic heart failure: systematic review and metaanalysis of randomized, double-blind, placebo-controlled trials. About half of these patients experienced long-lasting neurologic impairments. Injectable thiamine must be given by a healthcare professional. About 80% of the approximately 2530 mg of thiamin in the adult human body is in the form of thiamin diphosphate (TDP; also known as thiamin pyrophosphate), the main metabolically active form of thiamin. However, there is some evidence that the drugsLasix (furosemide) and Adrucil (fluorouracil)could cause the body to lose too much thiamine. It is especially found in people who have alcohol use disorder. Thiamin deficiency can cause loss of weight and appetite, confusion, memory loss, muscle weakness, and heart problems. However, some cases of this syndrome become so severe that people develop chronic (long-term) health problems, especially with memory. Fresh or dried fruits. Kopelman MD, Thomson AD, Guerrini I, Marshall EJ. A 2008 literature review identified 84 cases of Wernickes encephalopathy after bariatric surgery (primarily gastric bypass surgery) between 1991 and 2008 [35]. [, Butterworth RF, Besnard AM. Halal is an Arabic word means lawful or permitted. One of these studies found that 13% of 150 patients with cognitive impairment and acute-onset behavioral disturbances were considered thiamin deficient based on plasma levels [26]. This syndrome is serious and can even be deadly. Nolan KA, Black RS, Sheu KF, Langberg J, Blass JP. US national trends in bariatric surgery: A decade of study. [, Carpenter KJ. 2016;38:2277-2285. doi:10.1016/j.clinthera.2016.08.009, Kira J. 2013;10(4):26-32. At the same time, you will also be able to find another related term in Islamic food, mushbooh which means doubtful or suspect as it is unclear whether they are Halal or Haraam. [, Alaei Shahmiri F, Soares MJ, Zhao Y, Sherriff J. High-dose thiamine supplementation improves glucose tolerance in hyperglycemic individuals: a randomized, double-blind cross-over trial. Surgery. Preliminary findings of high-dose thiamine in dementia of Alzheimer's type. However, the authors recommend parenteral thiamin supplementation for patients at high risk, such as those with ataxia, confusion, and a history of chronic alcohol misuse, because oral supplementation is unlikely to produce adequate blood levels. In its early stage, thiamin deficiency can cause weight loss and anorexia, confusion, short-term memory loss, and other mental signs and symptoms; muscle weakness; and cardiovascular symptoms (such as an enlarged heart) [7]. Alcohol Alcohol. Arch Neurol 1988;45:833-5. Other newer studies found this was not the case after thiamine therapy. When beriberi is diagnosedand even when it is strongly suspectedthiamine supplementation is the treatment. The recommended daily allowance (RDA) of thiamine can vary by age and pregnancy status as follows, in milligrams (mg), which can be obtained through food sources or oral supplements: Note that Verywell Health prefers to use inclusive terminology, but when citing health authorities or studies, the terms relating to sex and gender from those sources are used. 2nd ed. As it in your old islamcan app No current data on rates of thiamin deficiency in the U.S. population are available. (e.g. In: Erdman JW, Macdonald IA, Zeisel SH, eds. [. The relevance of these effects to clinical prognosis or outcomes is not known. Severe thiamin deficiency leads to a disease called beriberi with the added symptoms of tingling and numbness in the feet and hands, loss of muscle, and poor reflexes. Thiamin also plays a role in muscle contraction and conduction of nerve signals. Diabetes Care 2010;33:1598-601. *. [, Agabio R. Thiamine administration in alcohol-dependent patients. These studies were not successful in determining what the dosage of thiamine should be to reverse the symptoms of this condition or to prevent it. Parrott J, Frank L, Rabena R, et al. -Styrene/Acrylates Copolymer These particular ingredients may or may not have animal derived ingredients or alcohol. [, Stracke H, Gaus W, Achenbach U, Federlin K, Bretzel RG. Ann Nutr Metab 2012;61:219-23. Thiamin is essential for the metabolism of pyruvate, which is an important . Furosemide (Lasix) is a loop diuretic used to treat edema and hypertension by increasing urinary output. 5 and others (Doubtful), Chocolate Liquour or Cocoa Liqour (Halal), Cream of Tarter (Halal in USA and Canada, elsewhere Doubtful), DATEM (Di- Acetyl Tartrate Ester of Monoglycerides) (Doubtful), Disodium Guanosine 5 Monophosphate (Haram), Disodium Uridine 5 Monophosphate (Haram), Enzymes used in Cheeses or Dairy Products (Doubtful), Ethoxylated Mono- and Diglycerides (Doubtful), Flour, Bleached Flour, Refined Flour, Enriched Flour (Halal), Isopropyl Alcohol or Isoproponal Alcohol (Halal), Microbial Enzymes, Rennet Microbial Enzymes and Lypase Microbial Enzymes (Halal), Modified Food Starch or Modified Starch (Halal), Monoglycerides and Diglycerides (Doubtful), Mustard, Mustard Seed, Mustard Oil (Halal), Partially Hydrogenated Vegetable Shortening (Halal), Polyglycerol Esters of Fatty Acids (Doubtful), Polyoxythylene Sorbitan Monostearate (Doubtful), Potassium (Bicarbonate, Bromate, Sorbate) (Halal), Sovent Extracted Modified Lecithin (Haram), Vanilla Beans or Vanilla Beans Speck (Haram), Vitamin B12: As Cyanocobalamin (Doubtful), Vitamin B5: As Pantotherric Acid (Doubtful), Hi there this list is very helpful for me, as I work in an elementary school delivering our nutrition program . Urine tests, which measure how much thiamine is being excreted, might also be used. The following products are definitely Halal: Milk (from cows, sheep, camels, and goats) Honey. [, Gibson GE, Sheu KF, Blass JP, Baker A, Carlson KC, Harding B, et al. Healthy adults, with an average diet of 2000 kcal, should aim for 1 mg of thiamin per day. J Endocrinol Invest 2012;35:951-6. Most people who eat a normal diet do not need extra. [, Alkhalaf A, Klooster A, van Oeveren W, Achenbach U, Kleefstra N, Slingerland RJ, et al. Halal Nicotinic acid/Niacin Nicotinic Acid is a vitamin manufactured through chemical synthesis, available as White Crystalline powder. 2013;7:CD004033. Cognitive impairment severity in relation to signs of subclinical Wernicke's encephalopathy in HIV and alcoholism comorbidity. Kosher Halal Vitamin B1 (Thiamin), is part of the group of essential nutrients known as the B Complex. -Hydroxypropyl guar hydroxypropyltrimonium chloride citrus fruit, tomatoes, etc). 2013;13:495-499. The role of thiamine in cancer: possible genetic and cellular signaling mechanisms. Is this your first time visiting our site? Modern Nutrition in Health and Disease. Severe acute metabolic acidosis and Wernicke's encephalopathy following chemotherapy with 5-fluorouracil and cisplatin: case report and review of the literature. What do you think? The result is typically 0%15% in healthy people, 15%25% in those with marginal deficiency, and higher than 25% in people with deficiency. Pork is another major source of the vitamin. Not enough is known about how thiamine supplements may help people with heart failure, and the authors of one meta-analysis are calling for more research. An analysis of data from the 2003-2006 National Health and Nutrition Examination Survey showed that only 6% of the U.S. population has a usual intake below the EAR [9]. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Verywell Health's content is for informational and educational purposes only. Some older small, randomized double-blind placebo-controlled trials showed that thiamine supplements improved one aspect of heart function in people with heart failure. 2021;170(1):13-17. doi:10.1016/j.surg.2021.02.002. Thiamin: One of the B complex vitamins. Pantotensyre (Vitamin B5) bidrager til normal mental ydeevne. This vitamin plays a critical role in energy metabolism and, therefore, in the growth, development, and function of cells [1]. Vitamin D: Natural sources are yeast and fish liver oil. [, Howard AJ, Kulkarni O, Lekwuwa G, Emsley HC. -Lauric acid Amber J. Tresca is a freelance writer and speaker who covers digestive conditions, including IBD. Nutritional deficiencies in obesity and after bariatric surgery. 2020;2020:9349063. doi:10.1155/2020/9349063. Thiamin (thiamine), or vitamin B1, is a water-soluble vitamin found naturally in some foods, added to foods, and sold as a supplement. Other vitamins and supplements may also be used as a treatment because other deficiencies might also be present. For more information about building a healthy dietary pattern, refer to the Dietary Guidelines for Americans and the U.S. Department of Agriculture's MyPlate. 2020;43:964-973. doi:10.14348/molcells.2020.0198, Allowitz KV, Yoo JJ, Taylor JR, et al. A thiamine deficiency can become serious, so its important for those who might lack it to be tested and receive a supplement. However, the authors of these studies did not assess the potential clinical significance of these findings. Thiamine for Alzheimer's disease. For example, bread has 20%30% less thiamin than its raw ingredients, and pasteurization reduces thiamin content (which is very small to begin with) in milk by up to 20% [3]. This may help in catching a deficiency early and getting the support to bring levels up to normal and avoid complications. If you continue to use this site we will assume that you are happy with it. Halal Vitamin B1 (Thiamine Hydrochloride and Thiamine Mononitrate) is a type of vitamin manufactured through chemical synthesis. J Am Geriatr Soc 2009;57:2166-8. The review authors stated that it was not possible to draw any conclusions from these three studies because they were small and the publications describing them did not provide enough detail to combine these data in a meta-analysis. Vitamin B1, or thiamin, helps prevent complications in the nervous system, brain, muscles, heart, stomach, and intestines. Although beriberi is rare in the United States and other developed countries, people in these countries do occasionally develop the condition [15-18]. Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs. Here is a comprehensive list of halal and haram ingredients. Nutr Rev. Eur J Nutr 2011;50:145-9. Healthcare providers may recommend a supplement to people taking those drugs. Hashimoto's Disease-Related Fatigue and Thiamine Levels, Beriberi as a Result of Thiamine (Vitamin B1) Deficiency, Taking on Vitamin Deficiencies in Hepatitis C, Guide to Dietary Supplements and Thyroid Disease. Lessons from diabetes. Acta Diabetol. For a reader-friendly overview of Thiamin, see our consumer fact sheet on Thiamin. Possible reasons include low dietary intakes, a combination of chronic diseases, concomitant use of multiple medications, and low absorption of thiamin as a natural result of aging [24,25]. In rare cases, beriberi causes congestive heart failure that leads to edema in the lower limbs and, occasionally, death [1,3]. Most people get enough thiamine in their food. Giving the supplement slowly and with fluids may help cut this risk, but there arent any accepted guidelines. Maybe. Thiamine injection is used to treat beriberi, a serious condition caused by prolonged lack of vitamin B1. In between halal and haram are doubtful ingredients. J Alzheimers Dis. TDP serves as an essential cofactor for five enzymes involved in glucose, amino acid, and lipid metabolism [1,3]. In addition to insufficient intakes of thiamin from the diet, the causes of thiamin deficiency include lower absorption or higher excretion rates than normal due, for example, to certain conditions (such as alcohol dependence or HIV/AIDS) or use of some medications [3]. Arch Neurol 1988;45:836-40. It's made with high-quality ingredients and all the essential vitamins and minerals to keep your heart +, brain, and eyes healthy and protected. These B vitamins, often referred to as B-complex vitamins, also help the body metabolize fats and protein. Seligmann H, Halkin H, Rauchfleisch S, Kaufmann N, Motro M, Vered Z, et al. Deficiencies are historically not common in developed areas of the world because most people get enough thiamine from food. Vitamins. Galvin R, Brathen G, Ivashynka A, Hillbom M, Tanasescu R, Leone MA. Estimate of bariatric surgery numbers, 2011-2020. Legumes and nuts like peanuts, cashew nuts, hazel nuts, walnuts, etc. Alcohol addiction, gut microbiota, and alcoholism treatment: a review. Thank you, {{form.email}}, for signing up. Without carrageenan, some products would not meet organic standards or vegetarian, halal, or kosher diets http://www.foodingredientfacts.org. Am J Physiol Gastrointest Liver Physiol 2012;303:G389-95. As a vitamin, Nicotinic acid/Niacin is general recognized as halal. Thiamin status is often measured indirectly by assaying the activity of the transketolase enzyme, which depends on TDP, in erythrocyte hemolysates in the presence and absence of added TDP [3]. Nutr J 2013;12:65. Updated: They then compared those who received the thiamine and those who didn't. Because of the lack of reports of adverse effects from high thiamin intakes (50 mg/day or more) from food or supplements, the FNB did not establish ULs for thiamin [7]. This article discusses the potential uses of thiamine. Therefore, this article makes it easier for you to find out if an ingredient is halal or . Meador K, Loring D, Nichols M, Zamrini E, Rivner M, Posas H, et al. Thiamine is absorbed in the small intestine. Larger, well-designed studies are needed to determine whether thiamin supplements are beneficial for Alzheimers disease. In highly industrialized countries, chronic alcohol use disorders appear to be the most common cause of thiamin deficiency [1]. Thiamine and cardiovascular disease: a literature review, The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure, Thiamine supplementation in symptomatic chronic heart failure: a randomized, double-blind, placebo-controlled, cross-over pilot study, High-dose thiamine supplementation in older patients with heart failure: a pilot randomized controlled crossover trial(THIAMINE-HF), Thiamin supplementation does not improve left ventricular ejection fraction in ambulatory heart failure patients: a randomized controlled trial, The effects of thiamine supplementation on patients with heart failure: a systematic review and meta-analysis of randomized controlled trials, Effects of thiamine on cardiac function in patients with systolic heart failure: systematic review and metaanalysis of randomized, double-blind, placebo-controlled trials, Benfotiamine and cognitive decline in Alzheimers disease: results of a randomized placebo-controlled phase IIA clinical trial, US national trends in bariatric surgery: A decade of study, Estimate of bariatric surgery numbers, 2011-2020, American Society for Metabolic and Bariatric Surgery integrated health nutritional guidelines for the surgical weight loss patient 2016 update: micronutrients, Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs, Aging with alcohol-related brain damage: Critical brain circuits associated with cognitive dysfunction, Alcohol addiction, gut microbiota, and alcoholism treatment: a review, Pathophysiology, prevention, and treatment of beriberi after gastric surgery, Cognitive impairment severity in relation to signs of subclinical Wernicke's encephalopathy in HIV and alcoholism comorbidity, Incidence of adverse reactions to parenteral thiamine in the treatment of Wernickes encephalopathy, and recommendations, Does long-term furosemide therapy cause thiamine deficiency in patients with heart failure? Some studies do show, however, that thiamin absorption increases when intakes are low [1]. Bacteria in the large intestine also synthesize free thiamin and TDP, but their contribution, if any, to thiamin nutrition is currently unknown [4]. The three studies randomly assigned fewer than 20 patients each, and the two crossover studies did not include a washout period [55-57]. It is used in some products to replace animal fats; in others, its used in place of gelatin, which is made from animal collagen. Blood thiamine levels in outpatients with diabetes mellitus. Organs. [, Cho IJ, Chang HJ, Lee KE, Won HS, Choi MY, Nam EM, et al. Ochsner J. The Dietary Guidelines for Americans describes a healthy dietary pattern as one that: This fact sheet by the National Institutes of Health (NIH) Office of Dietary Supplements (ODS) provides information that should not take the place of medical advice. I AM IN LOVE WITH A CHRISTIAN GIRL CAN I MARRY HER? Case Rep Med 2013;2013:709474. Have a question? Thiamin: One of the B complex vitamins. Am J Clin Nutr. Read our. Other health problems, such as diabetes, may worsen the condition. [. Pediatr Clin North Am 2009;56:1105-21. Vitamin A: If source are plant and synthetic, it is halal. Thiamin. Vitamins for Type 2 Diabetes: Whats Recommended? J Nutr 2011;141:1847-54. Encyclopedia of Dietary Supplements. *DV = Daily Value. The signs and symptoms of Wernicke-Korsakoff syndromecan include the following: Thiamine doesnt stay in the body for long, which is one reason deficiencies occur. We use cookies to ensure that we give you the best experience on our website. This makes thiamine levels important in diseases of the metabolic and gastrointestinal systems. The treatment includes supplementing with thiamine, but it may not cure it. Thiamine deficiency in patients with congestive heart failure receiving long-term furosemide therapy: a pilot study. Alcohol Alcohol 2006;41:151-8. Thiamine is used to treat or prevent vitamin B1 deficiency. This disorder is about 810 times more common in people with chronic alcoholism than in the general population, but it can also develop in patients who have severe gastrointestinal disorders, rapidly progressing hematologic malignancies, drug use disorders, or AIDS [2]. Korsakoff syndrome: an overlook (review). High-dose thiamine therapy for patients with type 2 diabetes and microalbuminuria: a randomised, double-blind placebo-controlled pilot study. It's not clear yet how thiamine may have an effect on diabetes. beberapa jenis pangan halal baik bahan maupun kemasan tugas pangan halal toyib telusur produk sertifikat halal disusun oleh: dorce sanda g2b221026 program studi. Because thiamin dissolves in water, a significant amount of the vitamin is lost when cooking water is thrown out [3]. Rapidly progressive polyneuropathy due to dry beriberi in a man: a case report. Some occur naturally in foods but might also be made synthetically in a lab. You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. Thiamine is a vitamin that is important to essential functions in the body. The published literature includes several cases of beriberi or Wernickes encephalopathy resulting from treatment with this drug, possibly because the drug might increase thiamin metabolism and block the formation of TDP, the active form of thiamin [60-63]. It's also used in our nervous system to help transmit nerve impulses and some other stuff that's hard to understand without a biochemistry degree! This section focuses on four diseases or disorders in which thiamin does or might play a role: Wernicke-Korsakoff syndrome, diabetes, heart failure, and Alzheimers disease. Korsakoffs psychosis, an effect of chronic thiamin deficiency, is associated with severe short-term memory loss, disorientation, and confabulation (confusion between real and imagined memories) [1-3]. AIDS. [, Essa E, Velez MR, Smith S, Giri S, Raman SV, Gumina RJ. They leave the body through the urine. Thiamine is vitamin B1, of which there are several different types that are used as supplements.
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