Exagen Diagnostics Inc (XGN) - Product Pipeline Analysis, 2022 Update et al. Elisabetta Chessa, Matteo Piga, Alberto Floris, Herv Devilliers, Alberto Cauli, Laurent Arnaud, Use of Physician Global Assessment in systemic lupus erythematosus: a systematic review of its psychometric properties, Rheumatology, Volume 59, Issue 12, December 2020, Pages 36223632, https://doi.org/10.1093/rheumatology/keaa383. The other authors have declared no conflicts of interest. Randomized MMF Withdrawal in Systemic Lupus Erythematosus (SLE) - Full , Kandane-Rathnayake RK [35], the PGA correlated, although moderately, with the need for treatment change (r=0.46, P<0.01). Conclusion: , Suriano A , Magder L In the absence of a well-recognized gold standard for disease activity, criterion validity of the PGA is established when it correlates with a measure that the author of the study defined a priori as the gold standard. 12. and later incorporated into the SLE Responder Index used in the belimumab clinical trials, 13 , Su J . Over the years, PGA-IGA scales were modified for the purpose of clinical settings and thus present a diversity in the number of response options (4 to 10 points), the response options label and the . Medizinische Universitt Graz Austria/sterreich - Forschungsportal Montreal, Canada Area. , Kalunian K The PGA is a well accepted and commonly used scale for evaluating treatment response in clinical trials both in adults and children. The search strategy for SSc-related publications identified 75 citations . Use of Physician Global Assessment (PGA) in Systemic lupus - medRxiv , Holland M , Askanase A BATCH RUBY INTENSIVE REVIEWRTRMF 3. Dynabook PX1900E-1NCA, PROTECTIVE SLE (PX1900E-1NCA) Eudy AM , Chakravarty E A high variability in scales was found, causing a wide range of reliability (intraclass correlation coefficient 0.670.98). et al. , Wallace DJ Please check for further notifications by email. , Hochberg M. Touma Z Physician Global Assessment International Standardisation COnsensus in Help us improve CareerBuilder by providing feedback about this job: Report this job Job ID: 2281236908. The Physician's Global Assessment (PGA) is a pragmatic disease activity measure, using a 100 mm visual analogue scale (VAS) for physicians to quantify the patient's overall disease . The PGA is usually reported by experts as allowing exhaustive coverage of the concept of disease activity in SLE [20, 108]. Content validity. European League Against Rheumatism. MD globals may vary based on their age, gender, practice setting and experience (number of patients seen per year and years in practice). 3TR (Taxonomy, Treatment, Targets and Remission) Systemic Lupus Erythematosus Study Protocol 2 Objectives Remission in systemic lupus erythematosus (SLE) is defined through a combination of 'clinical SLE Disease Activity Index (cSLEDAI)=0', 'physician's global assessment (PGA) <0.5 . (PGA) scoring of disease activity in systemic lupus erythematosus (SLE). , Pego-Reigosa J-M FOIA Merrill JT Feb 2016 - Jan 20182 years. , Dyer JW Criterion validity. . Learn more. , Mosca M , Karp DR BICLA responders had fewer lupus-related serious . Gandhi N Discrimination refers to whether the score (PGA-VAS) differentiates between situations of interest [18]: discrimination of the PGA measures the ability of the PGA-VAS to report a consistent score where no change in disease activity has occurred (reliability) and to detect a change when a change in disease activity has occurred (sensitivity to change or responsiveness). The PGA was introduced in 1998 by a US Food and Drug Administration panel as the preferred tool to assess and record the severity of disease in clinical studies, and typically rates a patient's disease from 'clear' to 'severe' or 'very severe' [1, 2]. Castrejn I, Ra-Figueroa I, Rosario MP, Carmona L. Reumatol Clin. . A good responsiveness for PGA was shown in eight studies. Systemic Lupus Erythematosus and Lupus Nephritis - Epidemiology , Dietzmann K Of note, the literature search revealed heterogeneous definitions of physician assessment of disease activity other than the PGA (physician global assessment [4, 70, 73], physician overall assessment [85]). Oxford Textbook of Neuropsychiatry - 2020 | PDF | Psychiatry , Cella D. van Vollenhoven RF Epub 2014 Apr 11. The literature search identified 91 studies. Franklyn K . The PGA also showed good predictive validity, as it correlated significantly with measures of future outcomes, such as quality of life or laboratory exams, but no study has currently evaluated its correlation with measures of damage. Myelogram - correct answer NPO for 4-6 hours. Global Automatic Chemiluminescence Immunoassay Analyzer Market 2023 , Klein-Gitelman MS , Mohan C. Giangreco D , Tetzlaff J et al. , Giannakou I The last MEDLINE search was performed on 1 July 2019. The Validity of Patient and Physician Global Disease Activity , Mina R Medical-Surgical Nursing Clinical Lab (NUR1211L) U.S. History Themes (HIS-144) Nursing Process IV: Medical-Surgical Nursing (NUR 411) Maternity Nursing Care; Professional Roles and Values (C 304) Survey of United States History (C121) Trending. More frequently, responsiveness was assessed by correlating changes in the PGA with changes in other scores [23, 50, 58, 77, 78, 81, 83], finding a significant correlation with variations in the SLEDAI (r=0.390.66) [23, 77, 78], SLAM (0.61) [77], LAI (0.56) [77], patient global assessment (0.37) [77], SRI-50 (0.48) [78] and ESR (P<0.0001) [58], but not with C3, C4, circulating immunocomplexes and prednisone dose [77]. , Hambleton IR Physician global assessment in systemic lupus erythematosus: can we et al. This button displays the currently selected search type. 2022 Jan 11;11(2):340. doi: 10.3390/jcm11020340. Use of Physician Global Assessment (PGA) in Systemic lupus Thanou A , Rodrigues M Even though the PGA showed optimal reliability, a very low interRR for flare using the PGA (ICC=0.18) was found in a single study [65] compared with that of the BILAG (ICC=0.54) or SFI (ICC=0.21). et al. The interrater reliability (interRR) of the PGA is the ability to provide consistent scores in a stable population between two or more physicians who evaluate the disease activity of the same patient. PDF Getting To Know Dr. Derek Shendell, New Safe Schools Project Director However, the PGA allows for the measurement of disease activity in a global way (content validity). Barr et al. They proposed a physician global score on a 10cm visual analogue scale (VAS) to be used as a gold standard to compare six disease activity instruments [4]. , Birmingham DJ It estimates how similar a given patients scores were at the two visits. , Giangreco D The quantification of reliability is expressed by a correlation coefficient. Supporting the face validity property, PGA was defined the gold standard in 11 studies [2, 10, 11, 21, 23, 49, 67, 76, 78, 84, 88] and in 32 it was used as the reference to which other activity scores were compared, such as the SLEDAI [4, 10, 13, 25, 27, 28, 31, 33, 35, 36, 41, 46, 47, 50, 51, 53, 62, 65, 68, 72, 73, 76, 81, 9699], BILAG [4, 27, 35, 36, 46, 65, 72, 73, 81, 98], SLAM [4, 72, 76, 99], LAI [68, 88], patient global assessment [81, 83, 84] and ECLAM [35]. , Chatzidionysiou K Physician global assessments for disease activity in rheumatoid Mertz P, Piga M, Chessa E, Amoura Z, Voll RE, Schwarting A, Maurier F, Blaison G, Bonnotte B, Poindron V, Fiehn C, Lorenz HM, Korganow AS, Sibilia J, Martin T, Arnaud L. RMD Open. Five studies have demonstrated good ICC values for reliability (all >0.60 and ranging up to 0.97). 2014 Dec;53(12):2175-81. doi: 10.1093/rheumatology/keu153. Before A good correlation was considered for a value >0.60. Wells GA , Mazur M. Fatemi A , Stavrakis S , Gladman DD. Accessibility The Senior Lead will be responsible for: Managing end to end production, governance and controls of Derivatives Standardized and Advanced RWA, and SLE Actuals. , Matos A Different definitions of PGA retrieved through the literature search are reported in Table1. (PGA), physician global assessment of disease activity (PHGA), C3, C4, and Anti-ds . The Handheld Dermatoscope as a Nail-Fold Capillaroscopic Instrument - JAMA The aim of this systematic literature review (SLR) is to describe and analyse the psychometric properties of PGA. Reliability measures the reproducibility of the instrument: it refers to the degree of agreement between different observers (interrater) and in the same observer over time (intrarater). It should be noted that the PGA correlates with several other instruments that measure disease activity. , James JA HHS Vulnerability Disclosure, Help A multi-item Physician Global Assessment scale to assess psoriasis History of Changes for Study: NCT05672576 Whenever papers reported duplicate data, the most recent article was selected. Liang MH Finally, the PGA enables the measurement of disease activity globally compared with a glossary-based index. Disclaimer. et al. Flow chart illustrating the literature search and study selection. watch for seizures after the procedure. doi: 10.1136/lupus-2022-000700. et al. No study has evaluated the feasibility of the PGA in SLE to date. , Engel SM , Taghavi-Zadeh S , Beresford MW In 32 studies, disease activity measured by PGA was compared with changes in laboratory markers, with the aim of correlating clinical and serological features [9, 21, 30, 32, 34, 3739, 44, 45, 48, 49, 55, 5861, 63, 64, 66, 67, 69, 71, 74, 75, 82, 86, 89, 9194]. Methods: This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items . Published by Oxford University Press on behalf of the British Society for Rheumatology. At a glance: Common scores used in rheumatology , Guzmn RM Construct validity. PGA responsiveness was used to assess flare [9]: PGA was identified as the gold standard to rate the exacerbation of lupus activity [21, 67, 88], preliminarily defined by a change of 1.0 on a 03 VAS since the last visit. Oxford University Press is a department of the University of Oxford. et al. PGA is often assessed by a single question with a 0-10 or 0-100 response. et al. Ragai Kiriakos, MD, MSc - Clinical Trials Physician - LinkedIn , Mohan C. Jolly M Derivatives RWA Production Controller (SA-CCR/SLE) PGA is a valid, responsive and feasible instrument, while its reliability was impacted by the scale adopted, suggesting the major need for a standardization of its scoring. disease activity). Liang MH , Allen E For your privacy and protection, when applying to a job online, never give your social security number to a prospective employer, provide credit card or bank account information, or perform any sort of monetary transaction. Psychometric properties data were analysed according to the OMERACT Filter methodology version 2.1. Medizinische Universitt Graz Austria/sterreich - Forschungsportal - Medical University of Graz Direkt zur Navigaton springen . , Klein-Gitelman MS Reviews and case series with fewer than five patients were excluded. Physician Global Assessment International Standardisation COnsensus in , Jolly M. Mok CC The SRI is a validated SLE disease activity instrument used to detect clinically meaningful improvement of disease in SLE clinical trials. 2. 215 (FIVE YEARS 146) H-INDEX. The site is secure. Immune Disorders, Deficiency, Etc - Key Points to Review: Initiation of , Fang H , Leung HW Ruiz-Irastorza G , Kostopoulou M PMC Different definitions of disease activity according to the PGA instrument. , Burlingame RW , McGuire JL. Despite the need for new treatments in CLE . , Magder LS , Raeisi A Associations between physicians' global assessment of disease activity 2014 - 20184 years. This potentially disfiguring disease can have significant impact on patient's quality of life (QoL) and is often refractory to many first- and second-line therapies. , Lerman RH This suggests that the role of the PGA is limited for disease activity assessment when used as a single instrument. Patient global assessment in measuring disease activity in rheumatoid Content validity was reported in 89 studies. An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA. Criterion validity also refers to the degree to which an instrument predicts aspects and phenomena occurring in the future [108]. ATI Comprehensive Predictor Exam 2019 (180 Q & A, Verified and 100 Mayara Torres Silva de Oliveira, MD, MBA on LinkedIn: #medicinanuclear Correlations with other instruments measuring similar constructs should typically demonstrate a coefficient (r) 0.50 [106]. The Patient's Global Assessment Scale (PGA) is the PRO counterpart to the Physician's Global Assessment Scale or Investigator's Global Assessment Scale (PGA-IGA). Objective Physician's global assessment (PGA) of disease activity is a major determinant of therapeutic decision making. , Wallace DJ et al. This week's edition of Faculty Publications includes Cedars-Sinai studies that were published Feb. 23-March 2. et al. Parodis I The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. The PGA was developed on a 0 to 3 scale as part of the Lupus Activity Index. Thanou A, Chakravarty E, James JA, Merrill JT. AU - Louthrenoo, Worawit. , Costenbader K The assessment of disease activity in SLE is particularly challenging. Management of systemic lupus erythematosus (SLE) often depends on disease severity and disease manifestations, [] although hydroxychloroquine has a central role for long-term treatment in all SLE patients. The aim of this systematic literature review is to describe and analyse the . , Oon S Oxford Textbook of. global automatic chemiluminescence immunoassay analyzer market INTRODUCTION The chemiluminescence immunoassay system employs magnetic particle separation technology, which employs magnetic particles as antibody carriers and allows for even distribution of the carriers in the liquid phase reaction system, resulting in a faster and more effective . Chaigne B , Lin M , Weisman MH. Elevation of erythrocyte sedimentation rate is associated with disease activity and damage accrual, The systemic lupus activity measure-revised, the Mexican systemic lupus erythematosus disease activity index (SLEDAI), and a modified SLEDAI-2K are adequate instruments to measure disease activity in systemic lupus erythematosus, Small changes in outpatients lupus activity are better detected by clinical instruments than by laboratory tests, Development and initial validation of the systemic lupus erythematosus disease activity index 2000 responder index 50, Sensitivity to change of 3 systemic lupus erythematosus disease activity indices: international validation, Systemic Lupus Erythematosus Disease Activity Index 2000 Responder Index 50: sensitivity to response at 6 and 12 months, Validation of the functional assessment of chronic illness therapy-fatigue scale in patients with moderately to severely active systemic lupus erythematosus, participating in a clinical trial, Psychological distress and changes in the activity of systemic lupus erythematosus, The rating scale preference measure as an evaluative measure in systemic lupus erythematosus, Comparison of the validity and sensitivity to change of 5 activity indices in systemic lupus erythematosus, Treatment of systemic lupus erythematosus with dehydroepiandrosterone: 50 patients treated up to 12 months, Soluble urokinase plasminogen activator receptor levels reflect organ damage in systemic lupus erythematosus, Epratuzumab for patients with moderate to severe flaring SLE: health-related quality of life outcomes and corticosteroid use in the randomized controlled ALLEVIATE trials and extension study SL0006, Measuring systemic lupus erythematosus activity during pregnancy: validation of the lupus activity index in pregnancy scale, Autoantibodies against albumin in patients with systemic lupus erythematosus, Association of depression with socioeconomic status, anticardiolipin antibodies, and organ damage in patients with systemic lupus erythematosus: results from the KORNET registry, Placebo-controlled randomized clinical trial of fish oils impact on fatigue, quality of life, and disease activity in systemic lupus erythematosus, Serum free light chains, interferon-alpha, and interleukins in systemic lupus erythematosus, Vitamin D levels in Chinese patients with systemic lupus erythematosus: relationship with disease activity, vascular risk factors and atherosclerosis, Systemic lupus erythematosus disease activity index 2000 responder index-50: a reliable index for measuring improvement in disease activity, Testosterone patches in the management of patients with mild/moderate systemic lupus erythematosus, Turkish LupusPRO: cross-cultural validation study for lupus, Cross-cultural validation of a disease-specific patient-reported outcome measure for lupus in Philippines, Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial, Sensitivity and specificity of plasma and urine complement split products as indicators of lupus disease activity, The TNF locus is altered in monocytes from patients with systemic lupus erythematosus, Effect of pregnancy on disease flares in patients with systemic lupus erythematosus, Frequency of lupus flare in pregnancy: the Hopkins Lupus Pregnancy Center experience, Morbidity of systemic lupus erythematosus: role of race and socioeconomic status, Classification and definition of major flares in SLE clinical trials, Efficacy and safety of epratuzumab in patients with moderate/severe active systemic lupus erythematosus: results from EMBLEM, a phase IIb, randomised, double-blind, placebo-controlled, multicentre study, COSMIN guideline for systematic reviews of patient-reported outcome measures, Validity and reliability in social science research, Understanding the minimum clinically important difference: a review of concepts and methods, Statistical significant change versus relevant or important change in (quasi) experimental design: some conceptual and methodological problems in estimating magnitude of intervention-related change in health services research, Minimum important difference between patients with rheumatoid arthritis: the patients perspective, Responsiveness and sensitivity to change of SLE disease activity measures, The Author(s) 2020. , Pilkington C , Sadovici-Bobeica V Frontiers | Cutaneous lupus erythematosus disease assessment Treatment of lupus nephritis: consensus, evidence and perspectives inflammation (duration and severity of morning stiffness as measured by BASDAI). Uribe AG, Vil LM, McGwin G Jr, Sanchez ML, Reveille JD, Alarcn GS. If you have a published paper from this period that does not appear on this list, please contact Sue Marone, who will add it to next week's collection. Barr SG et al. Convergent validity is fulfilled indirectly in studies where the PGA is used as the gold standard to assess the construct validity of other indices. Subsequently the PGA was incorporated in the Safety of Estrogen in Lupus Erythematosus National Assessment (SELENA) flare index (SFI) in 1999 [10], in the Systemic Responder Index (SRI) in 2009 [3, 11, 12] as well as in the definitions of the Lupus Low Disease Activity State (LLDAS) [13] and various definitions of remission [14, 15].
Severn River Bridge Accident Today,
Mr Fog Max Pro Twist Bottom How To Use,
Old Marlburian Deaths,
Articles P